Promoting Effect of Dedifferentiated Fat Cell Transplantation on Bone Formation in a Mouse Femoral Fracture Model

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  • Yamada Tomohiro
    Department of Orthopedic Surgery, Nihon University School of Medicine, Tokyo, Japan
  • Matsumoto Taro
    Department of Functional Morphology, Division of Cell Transplantation and Regeneration, Nihon University School of Medicine, Tokyo, Japan
  • Kazama Tomohiko
    Department of Functional Morphology, Division of Cell Transplantation and Regeneration, Nihon University School of Medicine, Tokyo, Japan
  • Arai Yoshinori
    Department of Oral and Maxillofacial Radiology, Nihon University School of Dentistry, Tokyo, Japan
  • Kano Koichiro
    Laboratory of Cell and Tissue Biology, Collage of Bioresource Science, Nihon University, Fujisawa, Japan
  • Tokuhashi Yasuaki
    Department of Orthopedic Surgery, Nihon University School of Medicine, Tokyo, Japan
  • Nakanishi Kazuyoshi
    Department of Orthopedic Surgery, Nihon University School of Medicine, Tokyo, Japan

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Other Title
  • マウス大腿骨骨折モデルにおける 脱分化脂肪細胞 (DFAT) 移植による骨形成促進効果
  • マウス ダイタイコツ コッセツ モデル ニ オケル ダツブンカ シボウ サイボウ(DFAT)イショク ニ ヨル コツ ケイセイ ソクシン コウカ

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Treatment for limb fractures is well established, but severe trauma and extensive bone loss may result in inadequate bone union, even with appropriate treatment and surgery. Recently, regenerative medicine using stem cells has been applied in the field of orthopedics. Dedifferentiated fat (DFAT) cells are mature adipocyte-derived multipotent cells that have characteristics similar to mesenchymal stem cells. In this study, we examined whether DFAT cell transplantation into the fracture site promotes bone formation in a mouse femoral fracture model. As a result, we found that DFAT cell transplantation promoted callus formation and increased bone volume around the fracture site. These results suggest that DFAT cells are an attractive cell source for the treatment of refractory fracture.

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