Less-Invasive Removal of Atherosclerotic Plaque Using Pulsed Lasers with a 5.75-μm Wavelength

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  • HASHIMURA Keisuke
    Department of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University Research Fellow of Japan Society for the Promotion of Science
  • ISHII Katsunori
    Department of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University
  • AWAZU Kunio
    Department of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University Gracuate School of Frontier Biosciences, Osaka University Grobal Center for Medical Engineering and Informatics, Osaka University

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  • 波長5.75 μmのパルスレーザーによる 動脈硬化プラークの低侵襲切削技術の開発
  • ハチョウ 5.75mm ノ パルスレーザー ニ ヨル ドウミャク コウカ プラーク ノ テイシンシュウセッサク ギジュツ ノ カイハツ

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Abstract

We report the current status of the less-invasive laser treatment of atherosclerosis with a 5.75-μm Wavelength. This selective treatment exploits characteristic absorption by biomolecules in the midinfrared range. With pulsed lasers, we achieved the selective removal of atherosclerotic plaque at 5.75 μm, which is the absorption peak of cholesteryl esters in atherosclerotic plaque. The absorption is derived from the C = O stretching vibration mode. This result demonstrated the effectiveness of the midinfrared region for advanced less-invasive treatments. However, for clinical applications, problems remain, such as the equipment size, ablation efficiency, and the thermal effect. Therefore, further progress of mid-infrared light sources is required.

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