Deviations in Hepatic Enzyme Levels in Children with Down Syndrome

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  • Okishio Emi
    Department of Pediatrics, St. Marianna University School of Medicine
  • Migita Ohsuke
    Department of Pediatrics, St. Marianna University School of Medicine
  • Hokuto Isamu
    Department of Pediatrics, St. Marianna University School of Medicine
  • Shimizu Naoki
    Department of Pediatrics, St. Marianna University School of Medicine

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Other Title
  • 無症候のダウン症児における肝逸脱酵素値に関する検討

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<p>Purpose: We investigated the values of deviant hepatic enzyme levels in asymptomatic children with Down syndrome and compared them with the reference values.<br/>Methods: We extracted follow-up blood sampling data of children with Down syndrome who visited the St. Marianna University School of Medicine from 2013 to 2018. We compared the data with the Japanese standard laboratory values for children.<br/>Results: The values of deviant hepatic enzymes in the children with Down syndrome were higher than the standard values and were frequently higher than the median values. Aspartate aminotransferase (AST) levels were twice as likely, and alanine aminotransferase (ALT) levels were 18 times as likely, to exceed the median values. Although many children with Down syndrome are obese, among the children whose values of deviant hepatic enzymes exceeded the standard values in our study, 85% of those under 18 years of age were not obese.<br/>Conclusions: In the present study, children with Down syndrome tended to have increased levels of AST and ALT.</p>

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