Synthesis of L-Iminofuranoses and Their Biological Evaluations

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  • Natori Yoshihiro
    Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University

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Other Title
  • L-イミノフラノース誘導体の合成とその生物活性評価に関する研究
  • L-イミノフラノース ユウドウタイ ノ ゴウセイ ト ソノ セイブツ カッセイ ヒョウカ ニ カンスル ケンキュウ

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<p>Iminosugars are one of the compounds that mimic the structure of monosaccharides. Such sugar mimics have the ability to effectively and specifically inhibit various glycosidases and glycosyltransferases. After studying iminopyranose, miglitol, which has α-glucosidase inhibitory activity, was approved and used in the clinical treatment of diabetes. This study focused on l-iminofuranose derivatives to develop new anti-diabetic drug. As a result, it was found that l-iminofuranose having an alkyl group at C1 position show potent α-glucosidase inhibitory activity. Further structural-activity relationship studies were conducted, and interesting findings were obtained. This paper describes the details of those research developments.</p>

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  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 141 (1), 15-24, 2021-01-01

    The Pharmaceutical Society of Japan

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