Four New Pregnane-10,2-carbolactones from an <i>Epipolasis</i> sp. Marine Sponge

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  • Kang Unwoo
    Molecular Targets Program, Center for Cancer Research, National Cancer Institute
  • Wang Dongdong
    Molecular Targets Program, Center for Cancer Research, National Cancer Institute
  • Bokesch Heidi R.
    Molecular Targets Program, Center for Cancer Research, National Cancer Institute Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
  • Gustafson Kirk R.
    Molecular Targets Program, Center for Cancer Research, National Cancer Institute

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  • Four New Pregnane-10,2-carbolactones from an Epipolasis sp. Marine Sponge

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Abstract

<p>Four new pregnane steroids, 3β,4β,16β-trihydroxypregna-5,17-diene-10,2-carbolactone (1), 16β-acetoxy-3β,4β-dihydroxypregna-5,17-diene-10,2-carbolactone (2), 12β-acetoxy-3β,4β,16β-trihydroxypregna-5,17-diene-10,2-carbolactone (3), and 12β,16β-diacetoxy-3β,4β-dihydroxypregna-5,17-diene-10,2-carbolactone (4) were isolated from an extract of an Epipolasis sp. marine sponge. The structures of the new compounds were determined by extensive NMR spectroscopic analysis and comparison with data from previously reported compounds.</p>

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