Absorption Kinetics of Ethanolamine Plasmalogen and Its Hydrolysate in Mice
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- Yamashita Shinji
- Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine
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- Fujiwara Kazufumi
- Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine
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- Tominaga Yuki
- Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine
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- Nguma Ephantus
- Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine
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- Takahashi Takumi
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- Otoki Yurika
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- Yamamoto Ayaka
- Yaizu Suisankagaku Industry Co., Ltd.
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- Higuchi Ohki
- Food and Biotechnology Platform Promoting Project, New Industry Creation Hatchery Center (NICHe), Tohoku University
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- Nakagawa Kiyotaka
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- Kinoshita Mikio
- Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine
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- Miyazawa Teruo
- Food and Biotechnology Platform Promoting Project, New Industry Creation Hatchery Center (NICHe), Tohoku University
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説明
<p>Ethanolamine plasmalogen (PlsEtn), a subclass of ethanolamine glycerophospholipid (EtnGpl), has been reported to have many biological and dietary functions. In terms of PlsEtn absorption, some studies have reported that PlsEtn is re-esterized at the sn-2 position using lymph cannulation and the everted jejunal sac model. In this study, we aimed to better understand the uptake kinetics of PlsEtn and increase its absorption. We thus compared the uptake kinetics of PlsEtn with that of the lyso-form, in which the fatty acid at the sn-2 position was hydrolyzed enzymatically. Upon administration of EtnGpl (extracted from oysters or ascidians, 75.4 mol% and 88.4 mol% of PlsEtn ratio, respectively), the plasma PlsEtn species in mice showed the highest levels at 4 or 8 hours after administration. In the contrast, administration of the EtnGpl hydrolysate, which contained lysoEtnGpl and free fatty acids, markedly increased the plasma levels of PlsEtn species at 2 h after administration. The area under the plasma concentration-time curve (AUC), especially the AUC0-4 h of PlsEtn species, was higher with hydrolysate administration than that with EtnGpl administration. These results indicate that EtnGpl hydrolysis accelerated the absorption and metabolism of PlsEtn. Consequently, using a different experimental approach from that used in previous studies, we reconfirmed that PlsEtn species were absorbed via hydrolysis at the sn-2 position, suggesting that hydrolysis in advance could increase PlsEtn uptake.</p>
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 70 (2), 263-273, 2021
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390849931334102528
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- NII論文ID
- 130007979436
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 031242421
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- PubMed
- 33456005
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可