Tissue Distribution of Exosomes and Other Extracellular Vesicles
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- FUTAGAMI Gaku
- Faculty of Pharmaceutical Sciences, Tokyo University of Science
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- KUSAMORI Kosuke
- Faculty of Pharmaceutical Sciences, Tokyo University of Science
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- NISHIKAWA Makiya
- Faculty of Pharmaceutical Sciences, Tokyo University of Science
Bibliographic Information
- Other Title
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- エクソソームを含む細胞外小胞の体内動態
- エクソソーム オ フクム サイボウ ガイ ショウホウ ノ タイナイ ドウタイ
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Description
<p>Exosomes are lipid bilayer-enclosed, nano-sized extracellular vesicles (EVs) which contain fingerprints of the cells that produce them, e.g., nucleic acids, proteins and lipids. Based on the close relationship of EVs including exosomes to various physiological and pathogenic conditions, EVs are expected to be applied to a wide range of diseases as diagnostic or therapeutic tools. Since EVs are known to exhibit diverse tissue distribution depending on their cell of origin and their subtypes, it is quite important to understand the tissue distribution properties of individual EVs. Therefore, researchers have been trying to elucidate the tissue distribution of EVs and to control it to increase the therapeutic potential of EVs as well as to expand their application as delivery vehicles for various pharmaceuticals, including low molecular weight compounds, proteins, and nucleic acids. In this review, we focus on small EVs with a diameter of about 100 nm, which include exosomes, and discuss about their tissue distribution, including their labeling methods, and approaches and technologies how to control it.</p>
Journal
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- Oleoscience
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Oleoscience 21 (2), 55-61, 2021
Japan Oil Chemists' Society
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Details 詳細情報について
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- CRID
- 1390850092193496832
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- NII Article ID
- 130007981012
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- NII Book ID
- AA11503417
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- ISSN
- 21873461
- 13458949
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- NDL BIB ID
- 031286015
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed