Relationships between Relative Expression of RND Efflux Pump Genes, H33342 Efflux Activity, Biofilm-Forming Activity, and Antimicrobial Resistance in Acinetobacter baumannii Clinical Isolates

DOI Web Site Web Site PubMed 参考文献20件
  • Kim Choon-Mee
    Premedical Science, College of Medicine, Chosun University, Republic of Korea
  • Park Geon
    Department of Laboratory Medicine, School of Medicine, Chosun University, Republic of Korea
  • Ko Young Jin
    Department of Laboratory Medicine, School of Medicine, Chosun University, Republic of Korea
  • Kang Seong-Ho
    Department of Laboratory Medicine, School of Medicine, Chosun University, Republic of Korea
  • Jang Sook Jin
    Department of Laboratory Medicine, School of Medicine, Chosun University, Republic of Korea

書誌事項

タイトル別名
  • Relationships between relative expression of RND efflux pump genes, H33342 efflux activity, biofilm-forming activity, and antimicrobial resistance in <i>Acinetobacter baumannii </i>clinical isolates

この論文をさがす

抄録

<p>Various mechanisms underlying antimicrobial resistance in Acinetobacter baumannii have been reported. There exists controversy regarding the relationships between efflux pump activity, biofilm formation, and antimicrobial resistance in A. baumannii. In this study, we investigated the relative expression of RND efflux pump genes, H33342 efflux activity, and biofilm-forming activity in 120 A. baumannii clinical isolates, examined their potential relationships with one another, and then statistically analyzed their effects on antibiotic resistance. High adeB expression and high H33342 efflux activity were correlated with low biofilm-forming activity. High adeB expression was significantly correlated with resistance to tigecycline and cefotaxime, but not with the multidrug resistance (MDR) phenotype. Importantly, only high adeJ expression was significantly correlated with the MDR phenotype, and was observed to be correlated with resistance to various antibiotics. However, we found no significant correlation between adeJ expression and biofilm-forming activity. Further, adeG expression was found to not be correlated with antibiotic resistance and biofilm-forming activity. The results of multivariate analysis showed that adeB overexpression and high H33342 efflux activity are related to biofilm-forming activity, and only adeJ overexpression is significantly associated with the MDR phenotype, highlighting the importance of adeJ overexpression.</p>

収録刊行物

参考文献 (20)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ