Outline of the Radiation Epidemiological Cohort Studies for Leukemia among Nuclear Workers and A-bomb Survivors

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  • 白血病を対象とした放射線業務従事者および原爆被爆者の疫学研究の概要

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Abstract

<p>The risk of leukemia related with radiation exposure was pointed out in a case report of a physician in 1911 and in subsequent reports. After that, many cohort studies among nuclear workers have been conducted in various countries on the leukemia risk at low dose and/or low dose rate radiation. However, these studies did not have consistent conclusions. INWORKS and UK NRRW cohort studies argued high risk with leukemia excluding chronic lymphocytic leukemia (CLL) mainly due to chronic myelogenous leukemia (CML), on the other hand, the 15-country study and J-EPISODE study did not show significant high risk of CML. There are some possibilities of this discrepancies and one of that may be based on lacking in statistical power because of that leukemia is a rare disease. Other possibilities of these discrepancies between these studies are based on the differences of dose rate, main component of cohorts, and statistical methods. In this paper, we summarize the subtypes of leukemia, baseline mortality by each study, and methods and results from the major radiation epidemiological studies.</p>

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