Triptolide reduces salivary gland damage in a non-obese diabetic mice model of Sjögren’s syndrome via JAK/STAT and NF-κB signaling pathways

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  • Guo Yunke
    Department of Rheumatism, Affiliated Hospital of Nanjing University of Chinese Medicine
  • Ji Wei
    Department of Rheumatism, Affiliated Hospital of Nanjing University of Chinese Medicine
  • Lu Yueyang
    Integration of traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine
  • Wang Yue
    Department of Rheumatism, Affiliated Hospital of Nanjing University of Chinese Medicine

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  • Triptolide Reduces Salivary Gland Damage in a Non-Obese Diabetic Mice Model of Sjogren’s Syndrome via JAK/STAT and NF-KappaB Signaling Pathways

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<p>Triptolide (TP) has anti-inflammatory and immunosuppressive effects. However, the effect of triptolide on Sjögren’s syndrome (SS) is rarely reported. In this paper, we studied the effects of triptolide on non-obese diabetes mice model of SS. In this study, salivary flow rate was measured every two weeks, and autoantibodies levels in the serum were detected. Salivary gland index and spleen index were detected, pathological changes of salivary gland were detected by hematoxylin-eosin staining, inflammatory factors were detected by enzyme linked immunosorbent assay, lymphocytes were detected by flow cytometry, proliferation of T cells and B cells were detected, and related proteins were detected by Western blot. Triptolide increased salivary flow rate and salivary gland index, and decreased spleen gland index. Moreover, triptolide reduced the infiltration of lymphocytes to salivary glands, decreased the level of autoantibodies in serum, and reduced the inflammatory factors in salivary glands and IFN-γ induced salivary gland epithelial cells. Further, triptolide inhibited activator of JAK/STAT pathway and NF-κB pathway. In conclusion, triptolide could inhibit the infiltration of lymphocytes and the expression of inflammatory factors through JAK/STAT pathway and NF-κB pathway. Thus, triptolide may be used as a potential drug to treat SS.</p>

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