Effects of Exogenous Biliverdin Treatment on Neurobehaviors in Mice
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- Li Yueyi
- Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University
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- Dong Yan
- Intensive Care Unit of Hebei Hospital of Traditional Chinese Medicine, Hebei University of Chinese Medicine
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- Meng Li
- Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University
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- Yu Panpan
- Department of State Assets and Laboratory Administrative, Hebei Medical University
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- Zhao Penghui
- Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University
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- Gong Miao
- Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University
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- Gao Qiang
- Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University
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- Shi Haishui
- Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medicinal University Hebei Key Laboratory of Neurophysiology, Hebei Medicinal University
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- Meng Cuili
- Department of Biochemistry, School of Basic Medicine, Xingtai Medical College
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- Gao Yuan
- Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medicinal University Hebei Key Laboratory of Neurophysiology, Hebei Medicinal University
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Abstract
<p>The neuroprotective effects of heme oxygenase (HO) have been well investigated. The potential effects of exogenous supplementation of biliverdin (BVD), one of the main products catalyzed by HO, on neurobehaviors are still largely unknown. The present study aimed to investigate the effects of BVD treatment on depression, anxiety, and memory in adult mice. Mice were injected with BVD through tail vein daily for a total 5 d, and depression- and anxiety-like behaviors were conducted by using open field test (OFT), novelty suppressed feeding (NSF), forced swimming test (FST) and tail suspension test (TST) since the third day of BVD administration. Novel object recognition (NOR) paradigm was used for memory formation test. After the final test, serum and hippocampal levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) of mice were analyzed by enzyme-linked immunosorbent assay (ELISA). The results showed that BVD treatment at low dose (2 mg/kg) induced depression-like behaviors, and high dose (8 mg/kg) BVD injection increased anxiety-like behaviors and impaired memory formation in mice. ELISA data showed that BVD treatment significantly increased hippocampal IL-6 and TNF-α level while only decreasing serum IL-6 level of mice. The present data suggest that exogenous BVD treatment induced depression- and anxiety-like phenotypes, which may be related to inflammatory factors, providing BVD may be a potential target for the prevention of mental disorders.</p>
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 44 (3), 325-331, 2021-03-01
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390850247500449408
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- NII Article ID
- 130007993407
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 031309366
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- PubMed
- 33642542
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed