Hedgehog signaling pathway in the adrenal gland
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- Takizawa Nae
- Departments of Urology and Andrology, Kansai Medical University
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- Tanaka Susumu
- Departments of Anatomy, Kansai Medical University
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- Matsuda Tadashi
- Departments of Urology and Andrology, Kansai Medical University
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- Yamada Hisao
- Departments of Anatomy, Kansai Medical University Faculty of Rehabilitation, Biwako Professional University of Rehabilitation
Bibliographic Information
- Other Title
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- 副腎皮質におけるヘッジホッグシグナル経路
- 副腎皮質におけるヘッジホッグシグナル経路 : Desert Hedgehogの発見
- フクジン ヒシツ ニ オケル ヘッジホッグシグナル ケイロ : Desert Hedgehog ノ ハッケン
- —detection of <i>Dhh</i>—
- ―Desert Hedgehogの発見―
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Description
<p>We identified a key signaling pathway associated with the adrenocortical autograft regeneration that has not been elucidated previously. Using the RNAscope technology, a novel in situ RNA hybridization assay, we found transient upregulation of Desert hedgehog (Dhh), a key signaling factor, and downregulation of Sonic hedgehog (Shh) in the process of graft regeneration. Interestingly, it had been reported that Dhh expression is localized to the gonadal tissues and its expression in the adrenal cortex has not been reported yet. Conversely, Shh-positive cells are known candidates for stem and progenitor cells in the adrenal cortex, but they exhibit little or no involvement in the process of adrenocortical graft regeneration. In addition to the previously known function of DHH in gonads, our findings suggest that it may further participate in the process of adrenocortical autograft regeneration. Our findings provide useful insights in the implementation of adrenal graft implantation and stem cell-derived adrenocortical cell generation. In this article, we will review our findings, the development of adrenal cortex, stem and progenitor cells, and other aspects.</p>
Journal
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- The Journal of Kansai Medical University
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The Journal of Kansai Medical University 71 (0), 1-6, 2020
The Medical Society of Kansai Medical University
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Keywords
Details 詳細情報について
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- CRID
- 1390850313415579520
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- NII Article ID
- 130007998548
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- NII Book ID
- AN00046712
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- ISSN
- 21853851
- 00228400
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- NDL BIB ID
- 031352092
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
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- Abstract License Flag
- Disallowed