Proposal of an in-vivo toxin model utilizing a porous media theory

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  • 多孔質体理論を活用した生体内毒素モデルの提案

Abstract

<p>In the present study, a general two-compartment model that can accurately evaluate the mass balance in the body was mathematically derived by adapting volume-averaging theory to the mass transfer around peripheral tissues. Introducing variable transformation, exact solutions of the proposed two-compartment model during and after dialysis were derived, and the validity of the proposed exact solutions was examined by comparing these solutions with clinical data and the numerical solution. A series of investigations revealed that the proposed two-compartment model can accurately reproduce the behavior of the measured blood urea concentration during and after dialysis.</p>

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