Serum Albumin and Risks of Stroke and Its Subtypes　― The Circulatory Risk in Communities Study (CIRCS) ―

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  • Li Jiaqi
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine
  • Imano Hironori
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Osaka Center for Cancer and Cardiovascular Disease Prevention
  • Yamagishi Kazumasa
    Osaka Center for Cancer and Cardiovascular Disease Prevention Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba Ibaraki Western Medical Center
  • Cui Renzhe
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine
  • Muraki Isao
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Osaka Center for Cancer and Cardiovascular Disease Prevention
  • Umesawa Mitsumasa
    Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba Department of Public Health, Dokkyo Medical University School of Medicine
  • Hayama-Terada Mina
    Osaka Center for Cancer and Cardiovascular Disease Prevention Yao City Public Health Center
  • Ohira Tetsuya
    Department of Epidemiology, Fukushima Medical University
  • Kiyama Masahiko
    Osaka Center for Cancer and Cardiovascular Disease Prevention
  • Okada Takeo
    Osaka Center for Cancer and Cardiovascular Disease Prevention
  • Sankai Tomoko
    Department of Community Health, Faculty of Medicine, University of Tsukuba
  • Tanigawa Takeshi
    Department of Public Health, Juntendo University School of Medicine
  • Kitamura Akihiko
    Osaka Center for Cancer and Cardiovascular Disease Prevention Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology
  • Iso Hiroyasu
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba
  • on behalf of the CIRCS Investigators

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<p>Background:Few studies have investigated the association between serum albumin levels and the risk of stroke subtypes among the general Japanese population.</p><p>Methods and Results:In this study, 5,071 men and 7,969 women aged 40–74 years, initially free from stroke, coronary artery disease, and kidney and hepatic failure, and residing in 4 Japanese communities completed a baseline risk factor survey between 1985 and 1994. During the 24-year follow-up, 528 men and 553 women experienced stroke. In the entire study cohort, multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) of total stroke, ischemic stroke, and intracerebral hemorrhage for the lowest vs. highest quartiles of serum albumin were 1.45 (1.18–1.77), 1.52 (1.17–1.97), and 1.57 (1.04–2.37), respectively. In men, multivariable HRs (95% CIs) for total stroke, ischemic stroke, and intracerebral hemorrhage in the lowest vs. highest serum albumin quartile were 1.44 (1.07–1.92), 1.48 (1.03–2.11) and 1.71 (0.92–3.18), respectively, whereas in women they were 1.50 (1.13–1.99), 1.63 (1.11–2.39), and 1.56 (0.89–2.74), respectively. Similar inverse associations were observed for each of the ischemic stroke subtypes, but not for subarachnoid hemorrhage.</p><p>Conclusions:Low serum albumin levels were associated with an increased risk of total stroke, ischemic stroke, ischemic stroke subtypes, and intracerebral hemorrhage.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 85 (4), 385-392, 2021-03-25

    一般社団法人 日本循環器学会

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