Human blood research of psychiatric disorders focusing on microglia hypothesis

DOI
  • Kato Takahiro A
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University
  • Ohgidani Masahiro
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University Department of Integrative Anatomy, Nagoya City University Graduate School of Medical Sciences
  • Setoyama Daiki
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University
  • Kubo Hiroaki
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University
  • Watabe Motoki
    School of Business, Monash University Malaysia
  • Kang Dongchon
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University
  • Kanba Shigenobu
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University

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Other Title
  • ヒト血液を用いた精神疾患ミクログリア仮説解明のための橋渡し研究

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Abstract

Microglia are immune cells in the brain, and microglia have recently been suggested to contribute to a variety of mental disorders. Herein, we introduce our novel reverse‐translational research system using peripheral bloods to clarify the underlying pathophysiology of microglial dysfunctions in mental disorders by analyzing plasma components (i. e. metabolomics) and by producing/analyzing induced microglia‐like (iMG) cells from monocytes. In this paper, we introduce our latest research especially focusing on plasma metabolomic analysis in patients with major depressive disorder.

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