Correlation between levels of medial temporal atrophy and scores of Rivermead Behavioural Memory Test in patients with early Alzheimer disease

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  • Nagayama Tomiko
    Department of Neurology, International University of health and Welfare, Atami Hospital
  • Nakayama Takuya
    Department of Rehabilitation, International University of Health and Welfare, Atami Hospital
  • Sato Kenshiro
    Department of Rehabilitation, International University of Health and Welfare, Atami Hospital
  • Yang Sunghoon
    Department of Neurology, International University of health and Welfare, Atami Hospital
  • Yamaguchi Shuhei
    Shimane Prefecture Bureau of Hospital Administration
  • Nagayama Masao
    Department of Neurology, International University of health and Welfare, Atami Hospital

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Other Title
  • 早期アルツハイマー病患者における側頭葉内側部の萎縮度とリバーミード行動記憶検査の得点との相関について
  • 早期アルツハイマー病患者における側頭葉内側部の萎縮度とリバーミード行動記憶検査の得点との相関について : ミニメンタルテストと比較して
  • ソウキ アルツハイマービョウ カンジャ ニ オケル ソクトウヨウ ウチガワブ ノ イシュクド ト リバーミード コウドウ キオク ケンサ ノ トクテン ト ノ ソウカン ニ ツイテ : ミニメンタルテスト ト ヒカク シテ
  • —ミニメンタルテストと比較して—

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Abstract

<p>Voxel-based specific regional analysis system for Alzheimer’s disease （VSRAD） is a new software program using magnetic resonance imaging （MRI） for the detection of early specific atrophy in Alzheimer’s disease （AD）.　The target volume of interest （VOI） is the medial temporal region involving hippocampus, amygdala, and the entorhinal cortex.　These regions, especially the hippocampus are concerned with memory function.</p><p>The purpose of this study was to assess whether there was a significant correlation between the severity score of atrophy in the target VOI and the Rivermead Behavioural Memory Test （RBMT） score that is a memory function test in everyday life scenes in the patients with early AD.</p><p>This study included 59 patients, and they were classified as FAST3 （borderline between normal and mild AD） or FAST4 （mild AD）.　The Mini-Mental State Examination （MMSE） that is the most widely used screening tool for detecting dementia and a general cognitive function test, and the RBMT were administered to all patients.　Out of the total patient pool, 32 patients were scanned with a 1.5Tesla MRI scanner and 27 patients were scanned with a 3Tesla MRI scanner.　Their levels of medial temporal atrophy were then analyzed by VSRAD using the brain MRI data.</p><p>We found that there were more significant correlations between the severity score of atrophy in the target VOI and the RBMT score than the MMSE score.</p><p>These findings suggest that the RBMT is useful in detecting the early AD.</p>

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