Heat-killed <i>Lactobacillus plantarum</i> L-137 attenuates obesity and associated metabolic abnormalities in C57BL/6 J mice on a high-fat diet

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  • YOSHITAKE Rieko
    Molecular Microbiology Group, Department of Infectious Diseases, Tropical Biosphere Research Center, University of The Ryukyus, Nishihara, Okinawa 903-0213, Japan
  • HIROSE Yoshitaka
    Molecular Microbiology Group, Department of Infectious Diseases, Tropical Biosphere Research Center, University of The Ryukyus, Nishihara, Okinawa 903-0213, Japan
  • MUROSAKI Shinji
    Nihon Pharmaceutical University, Kitaadachi-gun, Saitama 362-0806, Japan
  • MATSUZAKI Goro
    Molecular Microbiology Group, Department of Infectious Diseases, Tropical Biosphere Research Center, University of The Ryukyus, Nishihara, Okinawa 903-0213, Japan

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<p>Heat-killed Lactobacillus plantarum L-137 (HK L-137) has anti-allergic, antitumor, and antiviral effects in mice, as well as an anti-inflammatory effect in rats with metabolic syndrome through regulation of immunity. To evaluate the influence of HK L-137 on chronic inflammation in mice with diet-induced obesity, C57BL/6 J mice were fed a normal diet (16% of energy as fat) or a high-fat diet (62% of energy as fat) with or without 0.002% HK L-137 for 4 to 20 weeks. It was found that HK L-137 supplementation alleviated weight gain and elevation of plasma glucose, cholesterol, alanine aminotransferase, and aspartate transaminase levels in mice with diet-induced obesity. Expression of several inflammation-related genes, including F4/80, CD11c, and IL-1β, in the epididymal adipose tissue of these mice was significantly downregulated by HK L-137. In addition, plasma levels of lipopolysaccharide-binding protein, a marker of endotoxemia, tended to be decreased by administration of HK L-137. These findings suggest that HK L-137 supplementation ameliorates obesity-induced metabolic abnormalities and adipose tissue inflammation, possibly through improvement of intestinal permeability.</p>

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