The anti-aging effects of <i>Bifidobacterium longum</i> BB536 act by protecting against oxidative stress in <i>Caenorhabditis elegans</i>

DOI
  • Toda Kazuya
    Next Generation Science Institute R&D Division, Morinaga Milk Industry Co., Ltd.
  • Hara Sakiko
    Next Generation Science Institute R&D Division, Morinaga Milk Industry Co., Ltd.
  • Mitsuyama Eri
    Next Generation Science Institute R&D Division, Morinaga Milk Industry Co., Ltd.
  • Odamaki Toshitaka
    Next Generation Science Institute R&D Division, Morinaga Milk Industry Co., Ltd.
  • Yoshimoto Shin
    Next Generation Science Institute R&D Division, Morinaga Milk Industry Co., Ltd.
  • Xiao Jin-zhong
    Next Generation Science Institute R&D Division, Morinaga Milk Industry Co., Ltd.

Bibliographic Information

Other Title
  • 線虫における<i>Bifidobacterium longum</i> BB536による酸化ストレス耐性を誘導するシグナル伝達を介した抗老化作用

Search this article

Abstract

<p>　Bifidobacterium is a well-established probiotic that has been shown to have health benefits by numerous clinical reports and is commonly used as an ingredient in dairy products. In the present study, we investigated the anti-aging effects of Bifidobacterium longum subsp. longum BB536 using Caenorhabditis elegans. The effects of BB536 administration on lifespan, reactive oxygen species (ROS) accumulation, and gene expression were evaluated using wild-type, mutant, and paraquat-induced mitochondrial dysfunction C. elegans models. Compared with wild-type C. elegans administered Escherichia coli OP50, the BB536-administered group showed prolonged lifespans and suppressed ROS accumulation. Additionally, BB536 administration improved age-related declines in physical function and sarcomere structure. Administration of BB536 to the paraquat-induced mitochondrial dysfunction aging model resulted in elevated expression of antioxidant system genes, such as heat shock protein 70 (HSP70), superoxide dismutase 1, thioredoxin-1, and glutathione S-transferase 4. Interestingly, these effects disappeared in the p38 mitogen-activated protein kinase (MAPK)-mutant worms. These results suggest the anti-aging potential of BB536 acts by protecting against ROS stress through the MAPK cascade-signaling pathway, which is evolutionarily preserved throughout eukaryotes, including mammals.</p>

Journal

  • Milk Science

    Milk Science 70 (1), 3-13, 2021

    Japanese Dairy Science Association

Keywords

Details 詳細情報について

Report a problem

Back to top