Factors Determining the Efficacy of Recombinant Human Thrombomodulin in the Treatment of Sepsis-Induced Disseminated Intravascular Coagulation
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- Kotake Kazumasa
- Okayama Saiseikai General Hospital Department of Pharmacy
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- Hongo Takashi
- Okayama Saiseikai General Hospital Department of Emergency
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- Tahira Akihiro
- Okayama Saiseikai General Hospital Department of Pharmacy
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- Niimi Nana
- Okayama Saiseikai General Hospital Department of Pharmacy
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- Haisa Ikue
- Okayama Saiseikai General Hospital Department of Pharmacy
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- Kawakami Yasuhiro
- Okayama Saiseikai General Hospital Department of Pharmacy
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説明
<p>Recombinant human thrombomodulin (rhTM) is an anti-coagulant used to treat disseminated intravascular coagulation (DIC). The efficacy of rhTM in patients with sepsis-induced DIC has been proved in some clinical trials, but the determining factors are not known. The aim of this study was to identify patients for whom rhTM will be effective and the factors that determine rhTM efficacy in alleviating DIC. A single-center, retrospective, observational study was conducted in patients with sepsis-induced DIC who were treated with rhTM in Okayama Saiseikai General Hospital (Okayama, Japan) between January 2010 and December 2019. Among 67 patients who were treated with rhTM, DIC was resolved in 24 patients. The multivariate logistic regression analysis revealed that age (odds ratio (OR) 1.05; 95% confidence interval (CI) 1.00–1.10; p < 0.05) and acute physiology and chronic health evaluation II scores (OR 0.88; 95% CI 0.78–0.98; p < 0.05) were factors that determined rhTM efficacy in alleviating DIC. Overall, our study provides valuable information on factors that should be considered before rhTM administration to patients with sepsis-induced DIC for a better management of healthcare costs.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 44 (5), 605-610, 2021-05-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390850857223192832
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- NII論文ID
- 130008033184
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 031424782
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- PubMed
- 33612566
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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