Clinical significance of selenium deficiency in hemodialysis patients

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  • 透析患者におけるセレン欠乏症の臨床的意義
  • トウセキ カンジャ ニ オケル セレン ケツボウショウ ノ リンショウテキ イギ

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<p>Selenium is an essential trace element, which is found in the form of selenoproteins, such as glutathione peroxidase, thioredoxin reductase, and thyroxine deiodinase. Selenium deficiency can occur as a complication of cardiac dysfunction, atherosclerosis, infectious disease, hypothyroidism, malignancy, skin disorders, and muscle disorders. Selenium deficiency is of clinical relevance for patients under long‒term total parenteral nutrition or tube feeding as well as those with end‒stage renal disease. A couple of observational studies have revealed an association between low serum selenium concentrations and mortality. The Japanese KAREN study demonstrated that it contributes to death due to infectious disease, although interventional studies have been scarce. Since selenium deficiency can be involved in the development of infectious and cardiovascular disease, which are major two causes of death in Japanese dialysis patients, the diagnosis of and therapeutic strategy for selenium deficiency in dialysis patients should be considered.</p>

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