Desferrioxamine, an iron chelator, induces CXCL8 expression in U373MG human astrocytoma cells
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- Onda Kaoru
- Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
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- Yoshida Hidemi
- Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
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- Hayakari Ryo
- Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
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- Xing Fei
- Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
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- Wang Lian
- Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
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- Matsumiya Tomoh
- Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
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- Kawaguchi Shogo
- Department of Gastroenterology, Hirosaki University Graduate School of Medicine
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- Murakami Manabu
- Department of Pharmacology, Hirosaki University Graduate School of Medicine
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- Imaizumi Tadaatsu
- Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
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説明
Dysregulation of iron homeostasis in brain causes various neurodegenerative disorders. In fact, high concentration of iron is present in brains of patients with Alzheimer's disease. It was previously reported that CXCL8 protects human neurons from amyloid-β-induced neurotoxicity and that astrocytes have the potential to play important roles in Alzheimer's disease. In the present study, we examined the effect of desferrioxamine, an iron chelator, on the expression of CXCL8 in U373MG human astrocytoma cells used as a model of astrocytes. Treatment of the cells with desferrioxamine induced the expression of CXCL8. Pretreatment of the cells with FeSO₄ counteracted the positive effect of desferrioxamine on CXCL8 production, suggesting that the effect of desferrioxamine was due to iron chelation. RNA interference experiments showed that HIF-1α was not involved in desferrioxamine-induced CXCL8 expression. We conclude that desferrioxamine induces CXCL8 in astrocytes and the chelation of iron may be a new therapeutic strategy for Alzheimer's disease.
収録刊行物
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- 弘前医学
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弘前医学 66 (2-4), 127-134, 2016
弘前大学大学院医学研究科・弘前医学会
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詳細情報 詳細情報について
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- CRID
- 1390851165525366272
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- NII論文ID
- 130008046373
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- NII書誌ID
- AN00211444
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- ISSN
- 24344656
- 04391721
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- HANDLE
- 10129/5808
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- NDL書誌ID
- 027278154
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可