Desferrioxamine, an iron chelator, induces CXCL8 expression in U373MG human astrocytoma cells

Onda Kaoru, Yoshida Hidemi, Hayakari Ryo, Xing Fei, Wang Lian, Matsumiya Tomoh, Kawaguchi Shogo, Murakami Manabu, Imaizumi Tadaatsu

doi:10.32216/hirosakiigaku.66.2-4_127

Dysregulation of iron homeostasis in brain causes various neurodegenerative disorders. In fact, high concentration of iron is present in brains of patients with Alzheimer's disease. It was previously reported that CXCL8 protects human neurons from amyloid-β-induced neurotoxicity and that astrocytes have the potential to play important roles in Alzheimer's disease. In the present study, we examined the effect of desferrioxamine, an iron chelator, on the expression of CXCL8 in U373MG human astrocytoma cells used as a model of astrocytes. Treatment of the cells with desferrioxamine induced the expression of CXCL8. Pretreatment of the cells with FeSO₄ counteracted the positive effect of desferrioxamine on CXCL8 production, suggesting that the effect of desferrioxamine was due to iron chelation. RNA interference experiments showed that HIF-1α was not involved in desferrioxamine-induced CXCL8 expression. We conclude that desferrioxamine induces CXCL8 in astrocytes and the chelation of iron may be a new therapeutic strategy for Alzheimer's disease.

Desferrioxamine, an iron chelator, induces CXCL8 expression in U373MG human astrocytoma cells

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Desferrioxamine, an iron chelator, induces CXCL8 expression in U373MG human astrocytoma cells

この論文をさがす

説明

収録刊行物

キーワード

詳細情報 詳細情報について

書き出し

問題の指摘

詳細情報詳細情報について