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- サンダー スー ミヤット
- ヤンゴン第2医科大学 生理学部
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- ナイン チョー テット
- ヤンゴン第2医科大学 生理学部
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- セイン ミャ サンダ
- ヤンゴン第2医科大学 生理学部
書誌事項
- タイトル別名
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- Serum High-sensitivity C-reactive Protein Level and Corrected QT Interval in Agricultural Workers in Myanmar Exposed to Chronic Occupational Organophosphate Pesticides
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抄録
<p>Although acute organophosphate (OP) pesticide poisoning is associated with the risk cardiovascular diseases (CVD), the association between chronic occupational OP pesticide exposure and CVD risk is limited. We investigated serum high-sensitivity C-reactive protein (hs-CRP) levels and QTc intervals in 45 agricultural workers who were chronically exposed to OP pesticides and 45 non-exposed subjects. Serum hs-CRP level was determined by enzyme-linked immunosorbent assay (ELISA) and a level >1.0 mg/l was regarded as CVD risk. The QT interval was measured by routine 12-lead Electrocardiogram (ECG) with Lead II rhythm, and QTc was calculated. The median value of the serum hs-CRP level [1.20 (0.67–2.38) vs 0.74 (0.41–1.17) mg/l, P <0.05] and the mean QTc interval (422.71 ± 23.73 vs 396.27 ± 18.48 ms, P <0.0001) was significantly higher in the OP pesticide exposed subjects. Pesticide exposure was significantly associated with CVD risk (Chi-Square χ2 = 6.480, P = 0.011) and QTc interval prolongation (χ2 = 13.846, P <0.001). A higher risk of CVD (odds ratio = 3.030; 95% confidence interval = 1.276 – 7.197) was observed in the OP pesticide exposed subjects. This study suggested that OP pesticide exposure should be considered as one of the significant risk factors for CVDs.</p>
収録刊行物
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- Journal of UOEH
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Journal of UOEH 43 (2), 173-182, 2021-06-01
学校法人 産業医科大学
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詳細情報 詳細情報について
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- CRID
- 1390851198163723136
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- NII論文ID
- 130008048841
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- NII書誌ID
- AN0009832X
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- ISSN
- 21872864
- 0387821X
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- NDL書誌ID
- 031555426
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- PubMed
- 34092762
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可