An autopsy case of primary malignant lymphoma of the spleen with acute liver failure and respiratory failure

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  • Kotoh Yurika
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
  • Ishikawa Tsuyoshi
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
  • Sasaki Ryo
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
  • Oono Takashi
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
  • Matsuda Takashi
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
  • Saeki Issei
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
  • Hidaka Isao
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
  • Takami Taro
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
  • Itoh Hiroshi
    Department of Molecular Pathology, Yamaguchi University Graduate School of Medicine
  • Sakaida Isao
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine

Bibliographic Information

Other Title
  • 昏睡型急性肝不全および呼吸不全の病態を呈した脾原発悪性リンパ腫の1剖検例
  • コンスイガタ キュウセイ カンフゼン オヨビ コキュウ フゼン ノ ビョウタイ オ テイシタ ヒゲンパツ アクセイ リンパシュ ノ 1 ボウケンレイ

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Abstract

<p>A woman in her late 70s had complained of somnolence and difficulty moving. She had been found to have impaired liver function accompanied by disturbance of consciousness at another hospital, and was transferred to our hospital for treatment of hepatorenal dysfunction with disseminated intravascular coagulation. Abdominal ultrasonography and computed tomography showed significant splenomegaly and a low-density area of 13 mm in diameter in the spleen. Despite multidisciplinary treatment being initiated immediately, in addition to the liver and renal failure, respiratory failure due to bilateral diffuse alveolar hemorrhage occurred on the third day of hospitalization, so the patient was placed on ventilatory management. We could not determine the cause of these events during her clinical course, and she unfortunately died on the 17th day of hospitalization. Pathological autopsy finally led to the diagnosis of primary malignant lymphoma of the spleen (diffuse large B-cell lymphoma) with hepatic and pulmonary invasion.</p>

Journal

  • Kanzo

    Kanzo 62 (6), 349-356, 2021-06-01

    The Japan Society of Hepatology

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