Lipoprotein Particle Profiles Compared With Standard Lipids in the Association With Subclinical Aortic Valve Calcification in Apparently Healthy Japanese Men

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  • Vu Thien
    Center for Epidemiologic Research in Asia, Shiga University of Medical Science Division of Cardiovascular Surgery, Department of Surgery, Shiga University of Medical Science Department of Cardiac Surgery, Cardiovascular Center, Cho-Ray Hospital
  • Fujiyoshi Akira
    Department of Public Health, Shiga University of Medical Science Department of Hygiene, School of Medicine, Wakayama Medical University
  • Hisamatsu Takashi
    Department of Public Health, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Kadota Aya
    Center for Epidemiologic Research in Asia, Shiga University of Medical Science Department of Public Health, Shiga University of Medical Science
  • Zaid Maryam
    Center for Epidemiologic Research in Asia, Shiga University of Medical Science Department of Epidemiology, School of Public Health, Fudan University
  • Segawa Hiroyoshi
    Center for Epidemiologic Research in Asia, Shiga University of Medical Science
  • Kondo Keiko
    Center for Epidemiologic Research in Asia, Shiga University of Medical Science Department of Public Health, Shiga University of Medical Science
  • Torii Sayuki
    Department of Public Health, Shiga University of Medical Science
  • Nakagawa Yoshihisa
    Department of Cardiovascular Medicine, Shiga University of Medical Science
  • Suzuki Tomoaki
    Division of Cardiovascular Surgery, Department of Surgery, Shiga University of Medical Science
  • Asai Tohru
    Division of Cardiovascular Surgery, Department of Surgery, Shiga University of Medical Science Department of Cardiovascular Surgery, Juntendo University
  • Miura Katsuyuki
    Center for Epidemiologic Research in Asia, Shiga University of Medical Science Department of Public Health, Shiga University of Medical Science
  • Ueshima Hirotsugu
    Center for Epidemiologic Research in Asia, Shiga University of Medical Science Department of Public Health, Shiga University of Medical Science
  • for the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group

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<p>Background:Risk factors for atherosclerotic disease including dyslipidemia have been shown to be associated with aortic valve calcification (AVC). Nuclear magnetic resonance (NMR)-measured lipoprotein particles, low-density and high-density lipoprotein particles (LDL-p, HDL-p) in particular, have emerged as novel markers of atherosclerotic disease; however, whether NMR-measured particles are associated with AVC remains to be determined. This study aimed to examine the association between NMR-based lipoprotein particle measurements and standard lipids with AVC. The primary variables of interest were LDL-p (nmol/L), HDL-p (μmol/L), LDL-cholesterol, and HDL-cholesterol (both in mg/dL).</p><p>Methods and Results:A community-based random sample of Japanese men aged 40–79 years examined in 2006–2008, in Shiga, Japan was studied. Presence of AVC was defined as an Agatston score >0. Lipoprotein particles were measured using NMR spectroscopy. In the main analysis, multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for the prevalence of AVC across the higher quartiles of lipids in reference to the lowest ones were obtained. Of 874 participants analyzed, 153 men had AVC. Multivariable-adjusted ORs of prevalent AVC for the highest vs. the lowest quartile were significantly elevated for LDL-p (OR, 2.20; 95% CI: 1.23–3.93) and LDL-cholesterol (OR, 2.16; 95% CI: 1.23–3.78). In contrast, neither HDL-p nor HDL-cholesterol was associated with AVC.</p><p>Conclusions:The association of prevalent AVC with NMR-based LDL-p was comparable to that with LDL-cholesterol.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 85 (7), 1076-1082, 2021-06-25

    一般社団法人 日本循環器学会

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