Analysis of glycemic variability and insulin resistance in patients with pancreatic diabetes using a continuous glucose monitoring system

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  • Kon Akihito
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Tando Yusuke
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Yanagimachi Miyuki
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Tanaka Hikaru
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Matsuhashi Yuki
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Matsumoto Atsufumi
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Sato Eri
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Chikazawa Shinji
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Suda Toshihiro
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Nakamura Teruo
    Department of Medical Technology, School of Health Sciences, Hirosaki University

Bibliographic Information

Other Title
  • 持続血糖モニタリングシステムによる膵性糖尿病の血糖変動解析とインスリン抵抗性
  • Analysis of Glycemic Variabilit and Insulin Resistance in Patients with Pancreatic Diabetes Using a Continuous Glucose Monitoring System

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Abstract

    The purpose of this study was to analyze glycemic variability and insulin resistance of different types of diabetes, emphasizing mainly pancreatic diabetes, using Continuous Glucose Monitoring System (CGMS). The study involved a total of 59 patients receiving care at our department: 11 with pancreatic diabetes, 37 with type 2 diabetes, and 11 with type 1 diabetes. The CGMS data and several markers of insulin resistance were compared among the 3 groups and correlations were analyzed statistically. Standard deviation （SDCGMS） measured with CGMS and high molecular weight (HMW) adiponectin (Ad) as parameters of insulin resistance were identified as factors strongly affecting glycemic variability and insulin resistance. The magnitude of glycemic variability in patients with pancreatic diabetes was as large as that in patients with type 1 diabetes. Insulin resistance in patients with pancreatic diabetes was comparable to that in patients with type 1 diabetes. Our results suggest that CGMS data allow evaluation of both glycemic variability and insulin resistance in patients with pancreatic diabetes. HMW-Ad also appears to be a useful parameter of insulin resistance in patients with pancreatic diabetes.

Journal

  • Hirosaki Medical Journal

    Hirosaki Medical Journal 63 (2-4), 116-126, 2012

    Hirosaki University Graduate School of Medicine,Hirosaki Medical Society

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