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- Tanjoh Katsuhisa
- Medical Corporation Seito-Kai, Azuhata Hospital Department of Acute Medicine, Nihon University School of Medicine
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- Azuhata Takeo
- Medical Corporation Seito-Kai, Azuhata Hospital Department of Acute Medicine, Nihon University School of Medicine
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- Kawano Daisuke
- Medical Corporation Seito-Kai, Azuhata Hospital
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- Nakamura Kazuhiro
- Medical Corporation Seito-Kai, Azuhata Hospital
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- Ueno Yukihiro
- Medical Corporation Seito-Kai, Azuhata Hospital Sakuragawa Regional Medical Center
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- Tomita Ryouichi
- Medical Corporation Seito-Kai, Azuhata Hospital
Bibliographic Information
- Other Title
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- シンガタ コロナウイルス SARS-CoV-2 ニ ヨル COVID-19 ジュウショウカ ノ キジョ ト ジュウショウカ ヨソク マーカー ニ ツイテ
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Description
<p>COVID-19, a severe respiratory disease caused by the new coronavirus SARS-CoV-2, resulted in a worldwide pandemic that is still expanding. Although COVID-19 is primarily transmitted by droplet and contact routes, airborne transmission by aerosols also needs to be considered. The condition of approximately 20% of COVID-19 patients becomes severe and complicated by acute respiratory failure and multiple organ failure. Thrombus formation due to injury to vascular endothelial cells in each organ or tissue was recently shown to markedly increase disease severity. The cytokine storm caused by the activation of various immune cells due to SARS-CoV-2 infection and the direct invasion of vascular endothelial cells by SARS-CoV-2 through surface ACE2 as a receptor have been proposed to cause vascular endothelial cell injury. Elevated blood D-dimer, FDP, PT prolongation, and elevated blood IL-6 are useful markers for predicting aggravation.</p>
Journal
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- Journal of Japan Society for Homecare and Emergency Medicine
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Journal of Japan Society for Homecare and Emergency Medicine 4 (1), 38-46, 2020-12-31
Japan Society for Homecare and Emergency Medicine