Teratogenicity of Anti-testis Antiserum in Mice

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  • Teratogenicity of anti-testis antiserum
  • Teratogenicity of Anti‐testis Antiserum in Mice

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Abstract

ABSTRACT The teratogenicity of anti-testis antiserum was confirmed by an ex- periment using C57BL/6J mice. When the antiserum was administered intraperi- toneally to females on day 12.5 of pregnancy, reduction deformity of limbs and cleft palates were produced in the fetuses. Examinations of the internal organs and skeletons revealed no abnormality in the antiserum-treated mice. Immuno- histological analysis suggests the possibility that some antigen in the testis base- ment membrane may be involved.

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