Study on cause of death in rat neonates with congenital osteochondrodysplasia(ocd/ocd)-2-Functional abnormalities in central nervous system and respiratory muscle

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  • Study on Cause of Death in Rat Neonates with Congenital Osteochondrodysplasia(ocd/ocd) II. Functional Abnormalities in Central Nervous System and Respiratory Muscle
  • Study on cause of death in rat neonates

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ABSTRACT The rat with congenital osteochondrodysplasia with systemic sub- cutaneous edema (ocd/ocd) dies shortly after birth. It has been considered that the cause of death would be disturbed air flow from nose to lung by morphological abnormalities in respiratory tract. Respiratory rhythm was studied in the isolated and perfused preparation of brain stem-spinal cord-thorax in the ocd/ocd and phenotypically normal (+I?). The response of the isolated and perfused prepara- tion of thorax and diaphragm to the electrical stimulation was also studied. The spontaneous depolarizations of cervical ventral root C4 or C5 in the brain stem- spinal cord-thorax preparation were very low and infrequent in the ocd/ocd. The both tensions of the thorax and diaphragm preparations to the electrical stimula- tion were lower in the ocd/ocd than those in the +I?. Those results show that the cause of death in the ocd/ocd is not only morpho- logical abnormalities but also functional defects in the respiratory system including the central nervous system and muscles.

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