Effects of Folic Acid and Folinic Acid on Pyrimethamine Teratogenesis in Rats

DOI DOI DOI DOI Web Site ほか4件をすべて表示 一部だけ表示 被引用文献8件 参考文献11件

書誌事項

タイトル別名
  • Effects of folic acid and folinic acid

この論文をさがす

説明

ABSTRACT The effects of folic acid (FA) and folinic acid (FNA) on the tera-ｔogenicity of the antifolate drug pyrimethamine (PYR) were examined in rats. PYR and FA were orally administered with mashed feed. FNA was intraperitoneal- ly injected. The drugs were administered for 5 days of day 11-15 of gestation. Six groups were made; G-I PYR 1.6 (mg/kg/day), G-I1 PYR 3.6, G-111 PYR 1.6 + FA 50, G-IV PYR 3.6 + FNA 12, G-V FA 50, G-VI control. No malformations were found in G-I, IV, V and VI. All fetuses in G-I1 and 111 had malformations. Main malformations in G-I1 and 111 were cleft palate and brachygnathia. Accordingly it might be demonstrated that the teratogenicity of PYR was potentiated by concurrent FA in rats.

収録刊行物

被引用文献 (8)*注記

もっと見る

参考文献 (11)*注記

もっと見る

キーワード

問題の指摘

ページトップへ