Chemical Composition and in vitro Anti-inflammatory Activity of Wheat Germ Oil Depending on the Extraction Procedure

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  • Harrabi Saoussem
    Laboratory of Clinical Biochemistry, LR99ES11, Faculty of Medicine of Tunis, University of Tunis El Manar
  • Ferchichi Azza
    Laboratory of Clinical Biochemistry, LR99ES11, Faculty of Medicine of Tunis, University of Tunis El Manar
  • Fellah Hayet
    Laboratory of Clinical Biochemistry, LR99ES11, Faculty of Medicine of Tunis, University of Tunis El Manar
  • Feki Moncef
    Laboratory of Clinical Biochemistry, LR99ES11, Faculty of Medicine of Tunis, University of Tunis El Manar
  • Hosseinian Farah
    Food Science Program, Carleton University Institute of Biochemistry, Carleton University

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  • Chemical Composition and <i>in vitro </i>Anti-inflammatory Activity of Wheat Germ Oil Depending on the Extraction Procedure

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<p>This study aimed to examine the chemical composition of wheat germ oil extracted by three different methods, and to evaluate its inhibitory effect on the cyclooxygenase and proteinase activities. The results showed that the contents of policosanols, tocopherols and phytosterols were affected by the extraction procedure. However, the fatty acid composition of the different oil extracts was nearly the same. Among the tested oils samples, cold pressed oil exhibited the strongest inhibitory activity against proteinase (93.4%, IC50 =195.7 µg/mL) and cyclooxygenase 1 (80.5%, IC50 =58.6 µg/mL). Furthermore, the cold pressed oil had the highest content of octacosanol, β-sitosterol and α-linolenic acid, suggesting that those bioactive compounds could be essential for the potent ani-cyclooxygenase activity. The present data revealed that wheat germ oil contained cyclooxygenase and trypsin inhibitors, which are the promising therapeutic target for the treatment of various inflammatory diseases. Thus, wheat germ oil might be used to develop functional foods and pharmaceutic products for the human health.</p>

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