Insights into Pathology and Pathogenesis of Coronavirus Disease 2019 from a Histopathological and Immunological Perspective
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- Iida Shun
- Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
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- Arashiro Takeshi
- Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
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- Suzuki Tadaki
- Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
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<p>Since the first case of COVID-19 was reported in Wuhan, China, in December 2019, the SARS-CoV-2 epidemic has spread all over the world and has become a significant public health issue. The development of treatments for COVID-19 is currently in progress; however, their effects remain limited, and the development of more effective therapeutics is desired. Thus, sufficient understanding of the pathophysiology of COVID-19 is essential to develop effective therapeutics for this disease. Pathological analyses in particular play an important role to demonstrate the causal link between an infectious disease and the pathogen and elucidate the mechanism of pathogenesis. As per pathological analyses to date, respiratory organs are identified as the major affected organs in most COVID-19 cases; also, various lesions were noted in other organs. Further, there have been increasing reports that show that the immune responses of the host contribute to the deterioration of the pathological condition of COVID-19, and a novel concept of MIS-C/MIS-A is also being established. Thus, in this article, we have provided an overview of the pathology of COVID-19 from a histopathological and immunological perspective focusing on the mechanisms of COVID-19 pathogenesis.</p>
収録刊行物
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- JMA Journal
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JMA Journal 4 (3), 179-186, 2021-07-15
公益社団法人 日本医師会 / 日本医学会
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詳細情報 詳細情報について
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- CRID
- 1390851950115694080
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- NII論文ID
- 130008072940
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- ISSN
- 24333298
- 2433328X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 使用不可