Development of a short-term <i>in vivo</i> assay for thyroid hormone disrupting activity in maternal rats and their fetuses/pups as prescreening for potential developmental neurotoxicity: Propylthiouracil and phenobarbital examples. I. Findings in maternal rats and their fetuses

DOI

Bibliographic Information

Other Title
  • 発達神経毒性ポテンシャルのスクリーニングとしての短期in vivo甲状腺ホルモン影響評価法の開発：propylthiouracilおよびphenobarbitalの影響検出評価 I. 母動物と胎児に対する影響

Abstract

<p>While thyroid hormones (THs) are essential for brain development, effects of mild suppression of maternal blood THs by hepatic enzyme inducers on the infant brain developments is not fully understood. A simple screening test for investigating whether maternal chemical exposure reduces brain THs in fetal and neonatal rats would be valuable. To verify reliability of the Comparative Thyroid Assay with additional examination of the brain, THs and histology, propylthiouracil (PTU) and phenobarbital (PB) were dosed. Clearly suppressed THs in rat fetuses were noted with PTU but not with PB.</p>

Journal

Details 詳細情報について

  • CRID
    1390851961199049472
  • NII Article ID
    130008073624
  • DOI
    10.14869/toxpt.48.1.0_o-36
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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