Genome reprogramming-associated point mutations, frequency and mechanisms

DOI
  • ARAKI Ryoko
    Stem Cell Biology Group, Institute for Quantum Life Science, QST
  • HOKI Yuko
    Stem Cell Biology Group, Institute for Quantum Life Science, QST
  • SUGA Tomo
    Stem Cell Biology Group, Institute for Quantum Life Science, QST
  • SUNAYAMA Misato
    Stem Cell Biology Group, Institute for Quantum Life Science, QST
  • IMADOME Kaori
    Stem Cell Biology Group, Institute for Quantum Life Science, QST
  • KAMIMURA Satoshi
    Stem Cell Biology Group, Institute for Quantum Life Science, QST
  • NAKAMURA Miki
    Stem Cell Biology Group, Institute for Quantum Life Science, QST
  • FUJITA Mayumi
    Stem Cell Biology Group, Institute for Quantum Life Science, QST
  • ABE Masumi
    Quantum Life and Medical Science Directorate, QST

Bibliographic Information

Other Title
  • ヒトiPS細胞樹立におけるゲノム変異とその機構

Description

<p>There are great expectations for iPS cells as resources for regenerative medicine, and several clinical trials using iPSCs are already underway. However, some critical concerns still remain; genetic aberrations in iPS cells and their derivatives can cause immunogenicity and tumorigenicity. So far, we have focused on the genome instability, especially on point mutations, in reprogrammed pluripotent stem cells, iPSCs and ntESCs. Here we will discuss the genome reprogramming-associated genetic aberrations and the molecular mechanisms behind them, and we also report on an iPS cell system with a remarkable decrease in mutation frequency. </p>

Journal

Details 詳細情報について

  • CRID
    1390851961199094528
  • NII Article ID
    130008073885
  • DOI
    10.14869/toxpt.48.1.0_s3-3
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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