Methylmercury induces vulnerability against oxidative stresses via disruption of selenium-metabolism

DOI
  • KUDO Runa
    Division of Molecular-biology and Metabolism, Department of Pharmaceutical Sciences, Tohoku University
  • TOYAMA Takashi
    Division of Molecular-biology and Metabolism, Department of Pharmaceutical Sciences, Tohoku University
  • SAITO Yoshiro
    Division of Molecular-biology and Metabolism, Department of Pharmaceutical Sciences, Tohoku University

Bibliographic Information

Other Title
  • メチル水銀によるセレンメタボリズム撹乱を介した抗酸化システム脆弱化機構

Abstract

<p>Selenoprotein P (SeP) is a plasma protein that possesses 10 selenocysteine residues and supplies selenium to brain. Recently we’ve shown that methylmercury covalently modifies selenocysteines in SeP (Se-mercuration) by using our original methodologies. We’ve also found that Se-mercurations of SeP are robust and irreversible, although its biological and toxicological significances are not clear. Briefly, our present study suggested Se-mercuration of SeP causes inhibition of its selenium supplies, and besides resulting in induction of vulnerability against oxidative stresses. </p>

Journal

Details 詳細情報について

  • CRID
    1390851961199617536
  • NII Article ID
    130008073840
  • DOI
    10.14869/toxpt.48.1.0_p-3s
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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