Methylmercury induces vulnerability against oxidative stresses via disruption of selenium-metabolism
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- KUDO Runa
- Division of Molecular-biology and Metabolism, Department of Pharmaceutical Sciences, Tohoku University
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- TOYAMA Takashi
- Division of Molecular-biology and Metabolism, Department of Pharmaceutical Sciences, Tohoku University
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- SAITO Yoshiro
- Division of Molecular-biology and Metabolism, Department of Pharmaceutical Sciences, Tohoku University
Bibliographic Information
- Other Title
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- メチル水銀によるセレンメタボリズム撹乱を介した抗酸化システム脆弱化機構
Abstract
<p>Selenoprotein P (SeP) is a plasma protein that possesses 10 selenocysteine residues and supplies selenium to brain. Recently we’ve shown that methylmercury covalently modifies selenocysteines in SeP (Se-mercuration) by using our original methodologies. We’ve also found that Se-mercurations of SeP are robust and irreversible, although its biological and toxicological significances are not clear. Briefly, our present study suggested Se-mercuration of SeP causes inhibition of its selenium supplies, and besides resulting in induction of vulnerability against oxidative stresses. </p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 48.1 (0), P-3S-, 2021
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390851961199617536
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- NII Article ID
- 130008073840
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed