Total transferrin in cerebrospinal fluid is a novel biomarker for spontaneous intracranial hypotension
-
- Iijima Junko
- Departments of Biochemistry, Fukushima Medical University
-
- Hoshi Kyoka
- Departments of Biochemistry, Fukushima Medical University
-
- Ito Hiromi
- Departments of Biochemistry, Fukushima Medical University
-
- Kanno Mayumi
- Departments of Biochemistry, Fukushima Medical University
-
- Murakami Yuta
- Departments of Neurosurgery, Fukushima Medical University
-
- Takahashi Koichi
- Department of Neurosurgery, Sanno Hospital
-
- Matsumoto Kana
- Structural Glycobiology Team, Systems Glycobiology Research Group, RIKEN Global Research Cluster
-
- Yamaguchi Yoshiki
- Structural Glycobiology Team, Systems Glycobiology Research Group, RIKEN Global Research Cluster
-
- Nakajima Madoka
- Department of Neurosurgery, Juntendo University
-
- Miyajima Masakazu
- Department of Neurosurgery, Juntendo University
-
- Arai Hajime
- Department of Neurosurgery, Juntendo University
-
- Kanai Mitsuyasu
- Division of Neurology, Mihara Memorial Hospital
-
- Kitazume Shinobu
- Departments of Preparing Section for the School of Health Sciences, Fukushima Medical University
-
- Honda Takashi
- Departments of Human Life Sciences, Fukushima Medical University
-
- Hashimoto Yasuhiro
- Departments of Biochemistry, Fukushima Medical University
Search this article
Abstract
<p>Spontaneous intracranial hypotension (SIH) is caused by cerebrospinal fluid (CSF) leakage. Patients with SIH experience postural headaches, nausea, etc., due to CSF hypovolemia. Imaging studies and clinical examinations, such as radioisotope (RI) scintigraphy, are useful for diagnosing SIH. However, 20-30% of patients do not show typical morphology and clinical test results. We previously reported that CSF contains transferrin (Tf) isoforms:“brain-type” Tf derived from the choroid plexus and “serum-type” Tf derived from blood. We showed that both isoforms increased in the CSF of patients with SIH by Western blotting. In the present study, we demonstrate that conventional ELISA for quantifying total Tf is useful for diagnosing SIH more accurately than Western blotting. In addition, SIH with chronic subdural hematoma (CSDH) was also accurately diagnosed. Total Tf in the CSF can serve as a useful biomarker for diagnosing SIH with or without CSDH.</p>
Journal
-
- FUKUSHIMA JOURNAL OF MEDICAL SCIENCE
-
FUKUSHIMA JOURNAL OF MEDICAL SCIENCE 67 (2), 64-70, 2021
THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE
- Tweet
Keywords
Details
-
- CRID
- 1390852174975303424
-
- NII Article ID
- 130008079104
-
- NII Book ID
- AA0065246X
-
- ISSN
- 21854610
- 00162590
-
- PubMed
- 34373399
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed