Spontaneous clearance of serum hepatitis C virus RNA in an untreated patient with decompensated cirrhosis

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  • Matsumoto Moe
    Division of Gastroenterology and Hepatology, Shimada General Medical Center
  • Matsushita Masahiro
    Division of Gastroenterology and Hepatology, Shimada General Medical Center
  • Takeshita Yu
    Division of Gastroenterology and Hepatology, Shimada General Medical Center
  • Yokota Akihiko
    Division of Gastroenterology and Hepatology, Shimada General Medical Center
  • Hanaoka Tomohiko
    Division of Gastroenterology and Hepatology, Shimada General Medical Center
  • Uozaki Hiroki
    Division of Gastroenterology and Hepatology, Shimada General Medical Center
  • Watanabe Shin-ya
    Division of Gastroenterology and Hepatology, Shimada General Medical Center
  • Kanayama Hirokazu
    Division of Gastroenterology and Hepatology, Shimada General Medical Center
  • Ishibashi Kohei
    Division of Gastroenterology and Hepatology, Shimada General Medical Center
  • Kawata Kazuhito
    Hepatology Division, Hamamatsu University School of Medicine

Bibliographic Information

Other Title
  • 治療の機会に恵まれずに経過したC型慢性肝炎が，非代償性肝硬変にまで進展したのちにC型肝炎ウイルスの自然排除に至った1例
  • チリョウ ノ キカイ ニ メグマレズ ニ ケイカ シタ Cガタ マンセイ カンエン ガ,ヒダイショウセイ カンコウヘン ニ マデ シンテン シタ ノチ ニ Cガタカンエンウイルス ノ シゼン ハイジョ ニ イタッタ 1レイ

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Abstract

<p>A 56-year-old female with decompensated cirrhosis came to our hospital for antiviral treatment. The patient had a longer than 21-year history of chronic hepatitis C virus (HCV) infection; however, the patient was unable to receive antiviral treatment for varying reasons. After the first visit to our hospital, the patient was placed under observation and followed up because direct-acting antivirals for decompensated cirrhosis were not available at that point. Significant fluctuations in alanine aminotransferase levels and subsequent spontaneous clearance of HCV RNA were observed during regular outpatient visits. After HCV eradication, prompt normalization of serum levels of alanine aminotransferase, total bilirubin, and albumin was observed. Spontaneous clearance of HCV is associated with female gender, hepatitis B surface antigen positivity, younger age at diagnosis, lower HCV RNA titers, and interleukin-28B polymorphism. Furthermore, spontaneous clearance of HCV may be due to nonspecific stimulation of the immune system in a background of lower viral load in patients with liver cirrhosis.</p>

Journal

  • Kanzo

    Kanzo 62 (9), 555-560, 2021-09-01

    The Japan Society of Hepatology

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