Two Dogs with Serious Adverse Events After Emetic Treatment with Tranexamic Acid and an Adverse Event Questionnaire

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  • トラネキサム酸による催吐処置後に重篤な有害事象を生じた犬2例並びに催吐処置アンケート調査
  • トラネキサムサン ニ ヨル サイトショチ ゴ ニ ジュウトク ナ ユウガイ ジショウ オ ショウジタ イヌ 2レイ ナラビニ サイトショチ アンケート チョウサ

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Abstract

<p>Tranexamic acid (TXA) is recognized as a highly safe emetogenic agent and is most commonly used for emetic treatment in dogs in Japan. However, we experienced two patients each with serious adverse events after TXA emetic procedure. One patient died of shock after the administration of TXA. Histopathological examination revealed thrombosis of the pulmonary artery, diffuse hepatic congestion, and renal amyloid deposition. The other patient developed status epilepticus after TXA administration, which improved with the administration of antiepileptic drugs for several days. A questionnaire was send to clinical veterinarians to ascertain the occurrence of adverse events after TXA-induced emesis. The results showed that 15% of veterinarians had observed such adverse events. The most common adverse event was convulsion.</p>

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