Development of a Bicelle Lotion Containing a High Concentration of Ceramide

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  • 細胞間脂質の構造に着想を得たセラミド高配合化粧水の開発
  • サイボウ カン シシツ ノ コウゾウ ニ チャクソウ オ エタ セラミド コウハイゴウ ケショウスイ ノ カイハツ

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Abstract

<p>Ceramide is one of the main components of stratum corneum intercellular lipids and it plays an important role in barrier function. Although ceramide is a useful material for cosmetic products, it is difficult to stably mix into formulations, especially oil-poor formulations such as lotions, because of its highly crystalline nature. In stratum corneum intercellular lipids, ceramide forms flat lamellar structures with cholesterol, free fatty acids, and other lipids. Thus, we assumed that a flat shape would be suitable for the formulation of a stable ceramide mixture, and we focused on bicelle discoidal aggregates, which have a flat part composed of long-chain phospholipids and a rim composed of short-chain phospholipids or nonionic surfactants. We succeeded in preparing a translucent and stable lotion by mixing ceramide 2, hydrogenated soybean lecithin, and polyoxyethylene phytosterol ether in an appropriate ratio, and we confirmed that the lotion contained bicelles by transmission electron microscopy and X-ray diffraction. Differential scanning calorimetry showed that the crystalline structure of ceramide was weakened in the bicelles. X-ray diffraction indicated that the bicelle lotion formed a lamellar structure when it dried. These results suggest that bicelles can enable high concentrations of ceramide to be mixed stably into lotion, and that the bicelle lotion is occlusive. Since bicelles can be prepared without high-energy procedures such as high-pressure treatment, bicelle lotion is expected to be beneficial not only as a skincare item, but also as a sustainable formulation.</p>

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