The Different Effects of Acacetin and Biochanin A on Abnormal Contraction of Vascular Smooth Muscle

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  • ZHANG Min
    Department of Molecular and Cellular Physiology（PhysiologyⅠ.），Yamaguchi University Graduate School of Medicine

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  • 血管平滑筋の異常収縮に対するアカセチンとビオカニン Aの異なる効果について
  • ケッカン ヘイカツキン ノ イジョウ シュウシュク ニ タイスル アカセチン ト ビオカニン A ノ コトナル コウカ ニツイテ

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<p>Rho-kinase-mediated Ca2+-independent vascular abnormal contraction causes cerebral vasospasm after subarachnoid hemorrhage and vasospastic angina. We identified sphingosylphosphorylcholine（SPC）as the key molecule of Ca2+-independent contraction. The ideal condition for the</p><p>therapeutic agent for cerebral vasospasm is to specifically inhibit Ca2+-independent contraction without affecting Ca2+-dependent one. We found the ideal drug eicosapentaenoic acid（EPA），while EPA also suppressed vasospasm after subarachnoid hemorrhage clinically. However, lipophilic EPA can’t be administered intravenously. In this way, it’s urgent to find a new water-soluble compound.</p><p>We screened plant-derived compounds and focused on flavonoids, acacetin and biochanin A. Acacetin slightly inhibited 40 mM K+-induced contraction in porcine coronary vascular smooth muscle strips, but inhibited SPC-induced contraction fast and strongly. In contrast, biochanin A inhibited 40 mM K+-induced contraction more strongly than SPC-induced contraction. Both acacetin and biochanin A strongly inhibited SPC-induced Rho-kinase activation and myosin light chain</p><p>phosphorylation. The morphological changes induced by SPC in human coronary smooth</p><p>muscle cells were inhibited by acacetin and biochanin A.</p><p>In summary, the difference in the position of the phenyl group is involved in the inhibitory effect</p><p>on SPC-induced abnormal contraction in post administration.</p>

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