Crushing effect of red blood cell aggregation by acoustic pressure and evaluation of cell damages

DOI

Bibliographic Information

Other Title
  • 音響放射圧照射による赤血球凝集破砕効果及び損傷評価

Abstract

<p>The aggregation action of red blood cells (RBC) is interlocked with the increase of blood viscosity and plays the role of a blood flow inhibitor not only in human body but also in the extracorporeal circulation device. In our studies, search of suitable acoustic power for crushing the aggregations and damage evaluation of the RBC were carried out. The RBCs were microscopically observed and classified into following three stages, namely, shape-keeping, shape-changing, and dissipation. The experimental setup was consisted of a truncated cone container incorporated with a 28 kHz ultrasonic transducer in the center of the bottom. Porcine blood was used as the experimental sample and the RBC aggregations were controlled with the additive concentration of dextran 70. The crush of the RBC aggregation was confirmed by the Ultrasonic Peak Frequency Method. The indexes of cell damages were increased by the power and the time of the ultrasonic irradiation.</p>

Journal

Details 詳細情報について

  • CRID
    1390852714994269056
  • NII Article ID
    130008105530
  • DOI
    10.11239/jsmbe.annual59.523
  • ISSN
    18814379
    1347443X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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