Development of Artificial Heart Valve with a Membranous Cusp (Influence of Mechanical Anisotropy)

DOI

Bibliographic Information

Other Title
  • 膜状の弁尖をもつ人工心臓弁の開発（弁尖の力学的異方性が弁機能におよぼす影響）

Abstract

<p>We have been developing heart valve-like tissues (Biovalve) using in-body tissue architecture. Previously, we fabricated a novel prosthetic valve with a membranous tissue (Biosheet) as a valve cusp and an elliptical valve annulus. Because of isotropic mechanical properties of the valve, it was difficult to satisfy the performance of both opening and closing. The purpose of this study is to clarify the influence of mechanical property of anisotropic cusp on valve performance.The valve models were fabricated from a combination of polyurethane sheets and Ni-Ti wires. In-Vitro simulation was performed to evaluate valve performance and to observe its opening-closing behavior. The experimental conditions were set at the physiological condition of healthy adult male. According to ISO5840, temporal waveform of left atrial pressure, left ventricular pressure and mitral regurgitation were measured, and regurgitation rate, mean pressure gradient and effective orifice area were calculated to evaluate the valve performance.</p>

Journal

Details 詳細情報について

  • CRID
    1390852714994811776
  • NII Article ID
    130008105159
  • DOI
    10.11239/jsmbe.annual59.272
  • ISSN
    18814379
    1347443X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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