A case of severe hypothyroidism followed by transcatheter arterial chemoembolization with miriplatin-lipiodol suspension for the treatment of hepatocellular carcinoma

DOI Web Site Web Site 27 References
  • Nakamura Hironori
    Department of Internal Medicine, JA GIFU Koseiren Ibi Kosei Hospital
  • Hanai Tatsunori
    Department of Gastroentelogy/Internal Medicine, Gifu University Graduate School of Medicine
  • Mizukusa Takahisa
    Department of Internal Medicine, JA GIFU Koseiren Ibi Kosei Hospital
  • Hatakeyama Hiroo
    Department of Internal Medicine, JA GIFU Koseiren Ibi Kosei Hospital
  • Nishiwaki Shinji
    Department of Internal Medicine, JA GIFU Koseiren Ibi Kosei Hospital

Bibliographic Information

Other Title
  • 肝細胞癌に対するミリプラチンによるTACE施行後に診断された甲状腺機能低下症の1例
  • カン サイボウ ガン ニ タイスル ミリプラチン ニ ヨル TACE シコウ ゴ ニ シンダン サレタ コウジョウセン キノウ テイカショウ ノ 1レイ

Search this article

Abstract

<p>An 80-year-old male patient was diagnosed with hepatocellular carcinoma during follow-up after achieving a sustained virological response on interferon therapy for chronic hepatitis C. The tumor size was approximately 36 mm in diameter. We performed transcatheter arterial chemoembolization (TACE) with miriplatin-lipiodol suspension and gelation sponge material as treatment. Near-complete lipiodol retention was observed after TACE. However, the patient was readmitted due to dyspnea and anasarca on day 41 after TACE. Further investigation revealed myxedema caused by severe hypothyroidism. Tests for both anti-thyroid peroxidase antibody and anti-thyroglobulin antibody were negative. We started treatment with levothyroxine and gradually increased the dosage, after which FT4, FT3, and TSH levels gradually normalized. Thereafter, the patient's symptoms gradually improved. Therefore, administration of miriplatin suspension containing iodine may affect the development of hypothyroidism through the Wolff-Chaikoff effect.</p>

Journal

  • Kanzo

    Kanzo 62 (11), 756-764, 2021-11-01

    The Japan Society of Hepatology

References(27)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top