Effect of Jersey cow defatted dry milk on salivary volume and composition in elderly persons : a pilot study

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  • Pieczonka Tomasz D
    Department of Medical Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8504, Japan Present adress : Center of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland These authors contributed equally to this work
  • Bragiel-Pieczonka Aneta M
    Department of Medical Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8504, Japan Present adress : Department of Clinical Cytology, Centre of Medical Postgraduate Education, Marymoncka 99/103, 01-813 Warsaw, Poland These authors contributed equally to this work
  • Takeuchi Yuko
    Department of Oral Health Science and Social Welfare, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8504, Japan
  • Yanagisawa Shizuko
    Department of Oral Health Science and Social Welfare, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8504, Japan
  • Yoshioka Masami
    Department of Oral Health Science and Social Welfare, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8504, Japan Present adress : Department of Oral Health Sciences, Faculty of Health and Welfare, Tokushima Bunri University, 180, Nishihamaboji, Yamashiro-cho, Tokushima 770-8514, Japan
  • Ishikawa Yasuko
    Department of Medical Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8504, Japan

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<p>The administration of Leu57-Leu58-His59-Lys60 (LLHK), Leu58-His59-Lys60 (LHK), and His59-Lys60 (HK) from β-lactoglobulin C variant, which is specific to Jersey cow milk, has been shown to prevent and/or restore the age-dependent atrophy and functional decline of salivary glands by affecting gene expression in elderly rats. In this study, we investigated the effect of Jersey cow defatted milk on salivary volume and composition in elderly persons. Participants (aged 85 to 98, n = 8) were administered defatted dry milk from Jersey cows twice a day for 4 weeks. Before and after 4 weeks from the start of drinking, saliva was collected and weighed. Salivary cystatin S and amylase levels were analyzed by Western blotting. To assess the effect of Jersey cow defatted milk on taste perception, questionnaires were used. Salivary volume after oral administration of 40 g of Jersey cow defatted dry milk daily for 4 weeks was 1.8 times higher than that before administration. Salivary cystatin S and amylase levels significantly increased after administration of Jersey cow defatted dry milk. Moreover, all participants who had taste impairment reported improved taste perception after administration. The administration of Jersey cow defatted dry milk increased salivary volume and changed the composition of saliva in elderly persons. Furthermore, it improved taste perception. J. Med. Invest. 68 : 280-285, August, 2021</p>

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