Clinical Significance of Increased Computed Tomography Attenuation of Periaortic Adipose Tissue in Patients With Abdominal Aortic Aneurysms

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  • Yamaguchi Masao
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital
  • Yonetsu Taishi
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University
  • Hoshino Masahiro
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital
  • Sugiyama Tomoyo
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital
  • Kanaji Yoshihisa
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital
  • Yasui Yumi
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital
  • Nogami Kai
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital
  • Ueno Hiroki
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital
  • Nagamine Tatsuhiro
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital
  • Misawa Toru
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital
  • Hada Masahiro
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital
  • Sumino Yohei
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital
  • Hamaya Rikuta
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital
  • Usui Eisuke
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital
  • Murai Tadashi
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital
  • Lee Tetsumin
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University
  • Sasano Tetsuo
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University
  • Kakuta Tsunekazu
    Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital

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<p>Background:Recent imaging studies reported an association between vascular inflammation and progression of abdominal aortic aneurysm (AAA). This study investigated the clinical significance of periaortic adipose tissue inflammation derived from multidetector computed tomography angiography (MDCTA).</p><p>Methods and Results:Patients with asymptomatic AAA (n=77) who underwent an index and >6 months follow-up MDCTA examinations were retrospectively investigated. MDCTA analysis included AAA diameter and the periaortic adipose tissue attenuation index (PAAI). The PAAI was defined as the mean CT attenuation value within a predefined range from −190 to −30 Hounsfield units of adipose tissue surrounding the AAA. The growth rate of the AAA was calculated as the change in diameter. AAA progression (AP) was defined as an AAA growth rate ≥5 mm/year. Univariate and multivariate logistic regression analysis were performed to determine the predictors of AP. AP was observed in 19 patients (24.7%), the median baseline AAA diameter was 38.9 mm (interquartile range [IQR] 32.7–42.9 mm), and the median growth rate was 3.1 mm/year (IQR 1.5–4.9 mm/year). Baseline AAA diameter (odds ratio [OR] 1.16; 95% confidence interval [CI] 1.05–1.28; P=0.001) and PAAI (OR 1.12; 95% CI 1.05–1.20; P=0.004) were independent predictors of AP.</p><p>Conclusions:PAAI was an independent and significant predictor of AP, supporting the notion that local adipose tissue inflammation may contribute to aortic remodeling.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 85 (12), 2172-2180, 2021-11-25

    一般社団法人 日本循環器学会

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