Effects of <i>Paeonia albiflora</i> Root Extract on Epidermal Wound Healing
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- Hayashi Shota
- Research Center, Maruzen Pharmaceuticals, Co., Ltd.
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- Iwahashi Hiroyasu
- Research Center, Maruzen Pharmaceuticals, Co., Ltd.
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- Yashiki Keiko
- Research Center, Maruzen Pharmaceuticals, Co., Ltd.
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- Kiso Akinori
- Research Center, Maruzen Pharmaceuticals, Co., Ltd.
Bibliographic Information
- Other Title
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- 表皮創傷治癒に対するシャクヤク根エキスの効果
- ヒョウヒ ソウショウ チユ ニ タイスル シャクヤク コン エキス ノ コウカ
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Abstract
<p>Wound healing is a repair system which heals damaged tissue caused by external factors and is essential for maintaining biological homeostasis. Wound healing is impaired by aging. Topical agents and cosmetics have been used for the purpose of promoting wound healing. Herbal materials such as Aloe vera, Panax ginseng and Angelica acutiloba, which have been traditionally known to have beneficial effects on skin wound healing, are included in their formulations. In the process of epidermal wound healing, migration, proliferation, and differentiation of keratinocytes are indispensable, and many studies on the molecular mechanisms of epidermal wound healing have been reported. However, there are few reports about molecular mechanisms of herbal materials on epidermal wound healing effects. In this study, we focused on Paeonia albiflora root extract because it has been utilized in topical agents for skin wound care. Therefore, we examined promoting effects on migration, proliferation, and differentiation by Paeonia albiflora root extract in keratinocytes. As a result, Paeonia albiflora root extract promoted migration and proliferation, but it did not influence differentiation. The promoting effects of Paeonia albiflora root extract on migration and proliferation are caused by the increase of β-defensin-3 expressions and promoting ATP production and by the shortening of the S phase in the cell cycle, respectively. Furthermore, paeoniflorin, one of the components of Paeonia albiflora root extract, had the same effects except for the shortening of the S phase as the extract. In conclusion, it was suggested that Paeonia albiflora root extract and paeoniflorin could have promoting effects on epidermal wound healing.</p>
Journal
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- Journal of Society of Cosmetic Chemists of Japan
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Journal of Society of Cosmetic Chemists of Japan 55 (4), 331-337, 2021-12-20
The Society of Cosmetic Chemists of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390853423037777536
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- NII Article ID
- 130008131797
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- NII Book ID
- AN00101606
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- ISSN
- 18844146
- 03875253
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- NDL BIB ID
- 031893192
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed