A Case of Lung Adenocarcinoma with Autoimmune Hemolytic Anemia Developing After Immune Checkpoint Inhibitor Treatment
-
- Takata Naoki
- First Department of Internal Medicine, Toyama University Hospital
-
- Kambara Kenta
- First Department of Internal Medicine, Toyama University Hospital
-
- Tokui Kotaro
- First Department of Internal Medicine, Toyama University Hospital
-
- Taka Chihiro
- First Department of Internal Medicine, Toyama University Hospital
-
- Okazawa Seisuke
- First Department of Internal Medicine, Toyama University Hospital
-
- Imanishi Shingo
- First Department of Internal Medicine, Toyama University Hospital
-
- Miwa Toshiro
- First Department of Internal Medicine, Toyama University Hospital
-
- Hayashi Ryuji
- Department of Medical Oncology, Toyama University Hospital
-
- Sato Tsutomu
- Department of Hematology, Toyama University Hospital
-
- Tanaka Hiroaki
- Department of Internal Medicine, Shinseikai Toyama Hospital
-
- Inomata Minehiko
- First Department of Internal Medicine, Toyama University Hospital
Bibliographic Information
- Other Title
-
- 免疫チェックポイント阻害剤投与後に溶血性貧血をきたした肺腺癌の1例
Search this article
Abstract
<p>Background. Autoimmune hemolytic anemia is reported to be associated with the use of immune checkpoint inhibitors, and steroid therapy is recommended as the first choice of treatment. Case. A 61-year-old woman was treated with carboplatin+pemetrexed+pembrolizumab as first-line treatment for postoperative recurrence of lung adenocarcinoma. Anemia was detected at the start of the third-line treatment, and the patient was diagnosed with autoimmune hemolytic anemia based on the clinical course and increased peripheral blood reticulocyte count, increased serum levels of bilirubin and LDH, and a decreased serum level of haptoglobin. Treatment with prednisolone showed limited efficacy. She was started on rituximab in addition to steroid therapy, but died of progression of lung cancer 3 days after the initiation of rituximab therapy. Conclusion. The accumulation of cases of autoimmune hemolytic anemia associated with the use of immune checkpoint inhibitors is desired.</p>
Journal
-
- Haigan
-
Haigan 61 (7), 975-978, 2021-12-20
The Japan Lung Cancer Society
- Tweet
Details 詳細情報について
-
- CRID
- 1390853487386870784
-
- NII Article ID
- 130008136568
-
- ISSN
- 13489992
- 03869628
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed