書誌事項
- タイトル別名
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- Selective Reduction and Recovery of Invariant Vα24JαQ TCR T Cells in Correlation with Disease Activity in Patients with Chronic Graft-versus-Diseases
- Selective reduction and recovery of invariant V a 24J a Q TCR T cells in correlation with disease activity in patients with chronic graft versus diseases
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説明
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Natural Killer (NK) T cells regulate immune responses including autoimmunity and are selectively decreased in autoimmune disease. We investigated the regulatory role of CD4- CD8- double-negative (DN) invariant TCR Vα24JαQ T cells, a human counterpart of murine NK T cells, in the development of chronic graft-versus-host disease (GVHD) that resemble to autoimmune disease in clinical features. For this purpose, we monitored frequencies of invariant Vα24JαQ DN T cells in PBL from 8 bone marrow transplantation (BMT) patients, 4 of whom developed chronic GVHD. Invariant Vα24+ DN T cells were recovered at 3 mo. after BMT as a dominated population of DN Vα24 T cells. However, the recovery of these cells was delayed compared with that of conventional T cells. Furthermore, we found that invariant Vα24JαQ DN T cells were not detected at the onset of chronic GVHD and that invariant Vα24JαQ DN T cells were again found after successful treatment for chronic GVHD with prednisolone. These results indicate that the selective reduction of invariant Vα24JαQ DN T cells is related to the disease progression of chronic GVHD, suggesting that the NK T cells may regulate the development of chronic GVHD.
収録刊行物
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- 千葉医学雑誌 = Chiba medical journal
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千葉医学雑誌 = Chiba medical journal 85 (3), 113-124, 2009-06-01
The Chiba Medical Society
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詳細情報 詳細情報について
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- CRID
- 1390853647794982272
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- NII論文ID
- 10026994048
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- NII書誌ID
- AN00142148
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- ISSN
- 03035476
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- NDL書誌ID
- 10359789
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
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