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- 石原 淳
- 長崎大学生命医科学域
書誌事項
- タイトル別名
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- Chiral Lewis Acid-template Diels-Alder Reaction and the Application of Natural Product Synthesis
抄録
<p>The tethered Diels-Alder reaction is one of the most powerful and versatile methods for formation of functionalized cyclohexene derivatives with high regio- and stereoselectivity. Many advantages of the intramolecular Diels-Alder reaction have been extended to the intermolecular counterpart by linking the diene to the dienophile with a temporary tether. This account describes some highlights of template-mediated Diels-Alder reactions, together with our asymmetric Diels-Alder reaction of 2,4-dienols and methyl acrylate utilizing a bimetallic Lewis acid template derived from (R)-5,5’,6,6’,7,8,8’-octahydro-1,1’-bi-2-naphthol. The bimetallic Lewis acid-template Diels-Alder reaction is feasible to hetero-Diels-Alder reaction of 4-siloxy-2,4-penta-dienols and aldehydes to provide substituted dihydropyrans with good enantioselectivities. The synthetic application for biologically active compounds is also demonstrated.</p>
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 78 (3), 204-212, 2020-03-01
公益社団法人 有機合成化学協会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390853649405132416
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- ISSN
- 18836526
- 00379980
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可