Inhalative Administration of Insulin Using A New Bubble Jet Atomization Device

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  • Hisasue Junko
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka
  • Fukuyama Satoru
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka
  • Nakagaki Noriaki
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka
  • Moriwaki Atsushi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka
  • Inoue Sachiko
  • Sakurada Naoko
    Canon Inc., Tokyo
  • Kaneko Hideki
    Canon Inc., Tokyo
  • Takayama Koichi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka
  • Inoue Hiromasa
    Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan | Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka
  • Nakanishi Yoichi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka

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Other Title
  • 新規バブルジェット式霧化装置を用いたインスリンの経気道的投与

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Abstract

In this study, we attempted to perform inhalative administration of insulin using a newwbubble jetxatomization device based on ink jet printing technology and developed by Canon Inc. The aim of this study was to confirm the usefulness of the new device for achieving a hypoglycemic effect by insulin inhalation in normal rats. Methods : Inhaled insulin (15 U/kg) or a control solution without insulin was administrated to each Wistar rat intratracheally using the bubble-jet atomization device. Blood glucose concentrations were measured at 0, 10, 20, 30, 60, 90 and 120 min after administration of insulin or control solution. Results : The blood glucose concentrations in the inhaled insulin group were 63 ±10 mg/dl (20 min), 43 ± 8 mg/dl (60 min) and 35 ± 9 mg/dl (120 min), while those in the control solution group were 80±9 mg/dl (p = 0.016), 75 ± 10 mg/dl (p < 0.001) and 85 ± 27 mg/dl (p < 0.001). The blood glucose concentrations after administration of inhaled insulin were significantly lower than those after administration of control solution at all time points (p < 0.05) except 0 and 10 min. Conclusions : We confirmed the hypoglycemic effect of inhaled insulin using the new bubble jet atomization device. These results proved that the new device could atomize insulin while maintaining its bioactivity.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 102 (6), 215-222, 2011-06-25

    Fukuoka Medical Association

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