Differential Expression of Insulin-like Growth Factor 1 in Human Primary Liver Cancer

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  • 肝細胞癌におけるInsulin-like growth factor （IGF-1)発現に関する検討

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Abstract

Insulin-like Growth Factor 1(IGF-1) antigen was immunohistochemically examined in 28 patients of the primary hepatocellular carcinoma with hepatectomy. IGF-1 was expressed in 93% (26/28) of the primary lesion and 100% (28/28) of the normal liver. Compared with expression in normal liver, decreased expressions in primary lesions were noted in 36% (10/28) for IGF-1. Histological examination revealed that there were significant correlations between patients with decreased expressions of IGF-1 in primary lesions and poor differentiated hepatocellular carcinoma, and portal vein infiltration. These results indicate that expression of IGF-1 has the relationship with the differentiation in human primary hepatocellular carcinoma.

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  • 福岡醫學雜誌

    福岡醫學雜誌 104 (10), 334-338, 2013-10-25

    Fukuoka Medical Association

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